abstract：:There is clear evidence of lipoprotein oxidation in atherosclerotic lesions. Animal studies and observational prospective human cohort studies have been interpreted as supporting a role for antioxidants in the prevention of coronary heart disease (CHD). However, firm recommendations to take antioxidant supplements to ...

journal_title：Atherosclerosis

authors： Kritharides L,Stocker R

更新日期：2002-10-01 00:00:00

abstract：:Human serum paraoxonase (PON1) is an HDL-associated enzyme involved in the protection of lipoproteins from oxidation. A polymorphism at position 192 (Gln/Arg) influences its activity in a substrate-dependent manner. The aim of the present study was to evaluate, in vivo, the contribution of the PON1-192 polymorphism to...

journal_title：Atherosclerosis

authors： Gnasso A,Motti C,Irace C,Di Gennaro I,Pujia A,Leto E,Ciamei M,Crivaro A,Bernardini S,Federici G,Cortese C

更新日期：2002-10-01 00:00:00

abstract：:Elevated fibrinogen levels after coronary balloon angioplasty have been reported to be useful in predicting restenosis. Therefore, we sought to evaluate the relationship between preprocedural fibrinogen levels and the 6-12-month outcomes of patients undergoing coronary stenting. Plasma levels of fibrinogen were measur...

journal_title：Atherosclerosis

authors： Otsuka M,Hayashi Y,Ueda H,Imazu M,Kohno N

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Atherosclerotic plaques are heterogeneous with respect to inflammation, calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in pH and measured pH in living human carotid endarterectomized atherosclerotic plaques (CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aorta...

journal_title：Atherosclerosis

authors： Naghavi M,John R,Naguib S,Siadaty MS,Grasu R,Kurian KC,van Winkle WB,Soller B,Litovsky S,Madjid M,Willerson JT,Casscells W

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:We undertook a study to determine whether peripheral vascular disease of the lower extremity (PVD) per se affects the arterial viscoelastic properties and intima-media thickness (IMT) of the carotid and femoral arteries. METHODS:Thirty-five patients with PVD, 35 age- and gender-matched control subjects were...

journal_title：Atherosclerosis

authors： Cheng KS,Tiwari A,Baker CR,Morris R,Hamilton G,Seifalian AM

更新日期：2002-09-01 00:00:00

abstract：:To examine a long-term effect of community-based education program for hypercholesterolemia and an effect modification by apolipoprotein E polymorphism, we conducted a 1-year randomized clinical trial with 8 year-follow-up. One hundred four persons aged 40-64 years who had serum total cholesterol levels between 6.21 a...

journal_title：Atherosclerosis

authors： Iso H,Imano H,Nakagawa Y,Kiyama M,Kitamura A,Sato S,Naito Y,Shimamoto T,Iida M

更新日期：2002-09-01 00:00:00

abstract：:Some baboons accumulate appreciable amounts of large apoE-rich HDLs (HDL(1)) which are similar to those reported in humans with several different dyslipoproteinemias. We estimated HDL(1) cholesterol concentrations by gradient gel electrophoresis of serum samples obtained from 634 pedigreed baboons fed with three diets...

journal_title：Atherosclerosis

authors： Rainwater DL,Kammerer CM,Cox LA,Rogers J,Carey KD,Dyke B,Mahaney MC,McGill HC Jr,VandeBerg JL

更新日期：2002-08-01 00:00:00

abstract：:Apolipoprotein D (APOD, gene; apoD, protein) is a plasma high-density lipoprotein (HDL)-associated glycoprotein, with a putative role in the cholesterol (CHOL) transport pathway. An apoD protein polymorphism has been previously reported by us. The cathodically shifted pattern seen on isoelectric focusing gels, control...

journal_title：Atherosclerosis

authors： Desai PP,Bunker CH,Ukoli FA,Kamboh MI

更新日期：2002-08-01 00:00:00

abstract：:Monocytes and macrophages synthesize tissue factor (TF) which plays a role in thrombogenicity in coronary artery disease. This study was conducted to investigate the effect of Rho/Rho-kinase inhibition on the synthesis of TF in cultured human monocytes. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit...

journal_title：Atherosclerosis

authors： Nagata K,Ishibashi T,Sakamoto T,Ohkawara H,Shindo J,Yokoyama K,Sugimoto K,Sakurada S,Takuwa Y,Nakamura S,Teramoto T,Maruyama Y

更新日期：2002-07-01 00:00:00

abstract：:Numerous studies have found polymorphisms in the lipoprotein lipase (LPL) gene to be associated with the risk of coronary artery disease (CAD), implicating LPL in the development of atherothrombotic disease. It remains controversial, however, whether LPL acts in a pro- or anti-atherogenic fashion. We quantitated activ...

journal_title：Atherosclerosis

authors： Dugi KA,Schmidt N,Brandauer K,Ramacher D,Fiehn W,Kreuzer J

更新日期：2002-07-01 00:00:00

abstract：:beta-very low-density lipoprotein (beta-VLDL), a collective term for VLDL and chylomicron remnants, has recently shown to potently promote the development of atherosclerosis. However, the effects of beta-VLDL on the accumulation of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) in vascular smooth...

journal_title：Atherosclerosis

authors： Takahashi M,Takahashi S,Shimpo M,Naito A,Ogata Y,Kobayashi E,Ikeda U,Shimada K

更新日期：2002-06-01 00:00:00

abstract：:We evaluated a 69-year-old Japanese woman with apolipoprotein (apo) A-I deficiency, high levels of low-density lipoprotein (LDL)-cholesterol, hypertension and impaired glucose tolerance. The patient had corneal opacity, but neither xanthomas, xanthelasma, nor tonsillar hypertrophy. She was not symptomatic for coronary...

journal_title：Atherosclerosis

authors： Yokota H,Hashimoto Y,Okubo S,Yumoto M,Mashige F,Kawamura M,Kotani K,Usuki Y,Shimada S,Kitamura K,Nakahara K

更新日期：2002-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) can overcome a potential anti-angiogenic effect of TNF-alpha by inhibiting endothelial apoptosis induced by this cytokine. Soluble TNF-alpha receptor I (sTNFRI) is an extracellular domain of TNFRI and antagonizes the activity of TNF-alpha. Here we report that sTNFRI is able to...

journal_title：Atherosclerosis

authors： Sugano M,Tsuchida K,Tomita H,Makino N

更新日期：2002-05-01 00:00:00

abstract：:Enhanced and prolonged postprandial lipaemia is implicated in coronary and carotid artery disease. This study assessed the effects of atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on postprandial plasma concentrations of triglyceride-rich lipoproteins (TRLs). Sixteen middle-aged men with combined...

journal_title：Atherosclerosis

authors： Boquist S,Karpe F,Danell-Toverud K,Hamsten A

更新日期：2002-05-01 00:00:00

abstract：:Vascular endothelial cell death contributes to the progression of atherosclerotic lesion, and several transcriptional regulators are involved in the process. Activating transcription factor 3/liver regenerating factor-1 (ATF3/LRF-1), a stress-inducible transcriptional repressor, was shown to be highly expressed in vas...

journal_title：Atherosclerosis

authors： Nawa T,Nawa MT,Adachi MT,Uchimura I,Shimokawa R,Fujisawa K,Tanaka A,Numano F,Kitajima S

更新日期：2002-04-01 00:00:00

abstract：:Hypercholesterolemia impairs endothelial function. However, the production/release of nitric oxide from the hypercholesterolemic aorta is reported to be enhanced rather than impaired in animal studies. L-arginine improves endothelial function in hypercholesterolemic subjects. The goal of the present study was to inves...

journal_title：Atherosclerosis

authors： Kawano H,Motoyama T,Hirai N,Kugiyama K,Yasue H,Ogawa H

更新日期：2002-04-01 00:00:00

abstract：:In animal model studies, the uptake of chylomicron remnants after entering in the space of Disse occurs mainly by low-density lipoprotein (LDL) receptor and LDL receptor-related protein (LRP). In subjects, the relative importance of each one of these receptors for the clearance of chylomicron remnants is not fully und...

journal_title：Atherosclerosis

authors： Sposito AC,Santos RD,Hueb W,Ventura LI,Vinagre CC,Ramires JA,Maranhão RC

更新日期：2002-04-01 00:00:00

abstract：:Atherosclerotic calcification may weaken the aorta wall and thereby lead to rupture of the vessel. The mechanism whereby aortas undergo calcification remains unclear. Previous reports in this laboratory showed that, after 2 months of cholesterol-supplemental feeding, an increase in calcifiability of membrane vesicles ...

journal_title：Atherosclerosis

authors： Hsu HH,Camacho NC,Tawfik O,Sun F

更新日期：2002-03-01 00:00:00

abstract：:Homocysteine may promote atherogenesis and thrombogenesis by enhancing leukocyte-endothelium interactions. We explored this hypothesis in an acute hyperhomocysteinemia rat model, which was created by a continuous venous homocysteine infusion (4 ml/h/kg body weight) with 2.5 and 10 mg/ml D,L-homocysteine upto 90 min. V...

journal_title：Atherosclerosis

authors： Fu WY,Dudman NP,Perry MA,Wang XL

更新日期：2002-03-01 00:00:00

abstract：:Several reports have suggested an association between lipid peroxidation and human carotid atherosclerosis, but few reports have demonstrated a link between lipid peroxidation and carotid plaques in humans. In this study, we investigated the relationship between clinical features, histopathological characteristics and...

journal_title：Atherosclerosis

authors： Nishi K,Uno M,Fukuzawa K,Horiguchi H,Shinno K,Nagahiro S

更新日期：2002-02-01 00:00:00

abstract：:This prospective randomized trial was designed to elucidate clinically the effect of fluvastatin on inhibiting oxidation of the low density lipoprotein (LDL) and improving the vascular endothelial function as well as its lipid-lowering effects, in comparison with pravastatin. Of 64 consecutive dyslipidemic patients, 4...

journal_title：Atherosclerosis

authors： Inoue T,Hayashi M,Takayanagi K,Morooka S

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS:The occurrence of IHD was determined in Gilbert syndr...

journal_title：Atherosclerosis

authors： Vítek L,Jirsa M,Brodanová M,Kalab M,Marecek Z,Danzig V,Novotný L,Kotal P

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...

journal_title：Atherosclerosis

authors： Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：:Atherosclerotic plaque-like lesions are prevalent in synthetic arteriovenous shunts created to provide vascular access for hemodialysis. Similarities to atherosclerotic plaques in native arteries include eccentric location, immunoreactivity for smooth muscle actin, dystrophic calcifications, superimposed thrombi, and ...

journal_title：Atherosclerosis

authors： Sloop GD,Fallon KB,Zieske AW

更新日期：2002-01-01 00:00:00

abstract：:The enhanced production of endothelin-1 (ET-1) in atherosclerotic arteries may be related to increased activity of the endothelin converting enzyme (ECE) which converts big ET-1 to ET-1. The purpose of the present study was to investigate whether the vasoconstrictor activity of big ET-1 is altered as a result of incre...

journal_title：Atherosclerosis

authors： Böhm F,Johansson BL,Hedin U,Alving K,Pernow J

更新日期：2002-01-01 00:00:00

abstract：:Extracellular-superoxide dismutase (EC-SOD) is the major SOD isozyme in the arterial wall and may be important for antioxidation capability of the vascular wall and normal vascular function. EC-SOD is expressed in various cell types in the vascular wall such as fibroblasts, smooth muscle cells and macrophages, and the...

journal_title：Atherosclerosis

authors： Adachi T,Hara H,Yamada H,Yamazaki N,Yamamoto M,Sugiyama T,Futenma A,Katagiri Y

更新日期：2001-12-01 00:00:00

abstract：:Endurance exercise training is known to produce favorable changes in the metabolic profile including reduced plasma triglyceride (TG) and increased high-density lipoprotein (HDL) cholesterol concentrations. These metabolic improvements are likely to contribute to the reduced coronary heart disease (CHD) risk often obs...

journal_title：Atherosclerosis

authors： Bergeron J,Couillard C,Després JP,Gagnon J,Leon AS,Rao DC,Skinner JS,Wilmore JH,Bouchard C

更新日期：2001-12-01 00:00:00

abstract：:Short-term exercise training has been associated with improved endothelial-dependent vasodilation, but the impact of long-term habitual physical activity on vascular reactivity is not established. We studied the correlation between self-reported, habitual physical activity and vasoreactivity in non-smoking, non-diabet...

journal_title：Atherosclerosis

authors： McKechnie R,Rubenfire M,Mosca L

更新日期：2001-12-01 00:00:00

abstract：:Atherosclerosis is responsible for approximately 50% of all mortalities in the USA, Europe, and Japan. An innovative approach for investigating atherosclerotic lesions using a thermodynamic model and a boundary value model and an analytical example of a human abdominal aorta vessel with an initial lesion are presented...

journal_title：Atherosclerosis

authors： Wang HH

更新日期：2001-11-01 00:00:00

abstract：:In the present study apoA-I (Lys 107del), a naturally occurring human apoA-I variant with a deletion of Lys 107, was expressed in E. coli to examine the effect of this mutation on lipid binding, cholesterol efflux and lecithin:cholesterol acyltranferase (LCAT) activation. Dimyristoyl phosphatidylcholine (DMPC) binding...

journal_title：Atherosclerosis

authors： Huang W,Matsunaga A,Li W,Han H,Hoang A,Kugi M,Koga T,Sviridov D,Fidge N,Sasaki J

更新日期：2001-11-01 00:00:00

abstract：:The aim of this study was to examine whether the well-established effect of the common TaqIB polymorphism in intron 1 of the gene for cholesterol ester transfer protein (CETP) on high density lipoprotein cholesterol (HDL-C) concentration and increased risk of myocardial infarction (MI), could be explained by the recen...

journal_title：Atherosclerosis

authors： Eiriksdottir G,Bolla MK,Thorsson B,Sigurdsson G,Humphries SE,Gudnason V

更新日期：2001-11-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) A-chain contributes to the pathogenesis of cardiovascular proliferative diseases, such as hypertensive vascular disease, atherosclerosis, and re-stenosis of an artery after angioplasty. To develop a ribozyme against human PDGF A-chain mRNA as a gene therapy for human arterial prol...

journal_title：Atherosclerosis

authors： Hu WY,Fukuda N,Kishioka H,Nakayama M,Satoh C,Kanmatsuse K

更新日期：2001-10-01 00:00:00

abstract：:Colesevelam hydrochloride is a novel, potent, non-absorbed lipid-lowering agent previously shown to reduce low density lipoprotein (LDL) cholesterol. To examine the efficacy and safety of coadministration of colesevelam and atorvastatin, administration of these agents alone or in combination was examined in a double-b...

journal_title：Atherosclerosis

authors： Hunninghake D,Insull W Jr,Toth P,Davidson D,Donovan JM,Burke SK

更新日期：2001-10-01 00:00:00

abstract：:Self-administration of anabolic-androgenic steroids to increase muscular strength and lean body mass has been used widely among athletes. Flow mediated dilatation (FMD) determined by ultrasound of the brachial artery is accepted as both an in vivo index of endothelial function and an indicator for future atheroscleros...

journal_title：Atherosclerosis

authors： Ebenbichler CF,Sturm W,Gänzer H,Bodner J,Mangweth B,Ritsch A,Sandhofer A,Lechleitner M,Föger B,Patsch JR

更新日期：2001-10-01 00:00:00

abstract：:Cilostazol is an antiplatelet drug, which has beneficial effects in treatment of intermittent claudication and decreases serum triacyiglycerol level in these patients. In this study, we examined adipogenic potency of cilostazol using 3T3-L1 preadipocyte cell line because cilostazol is one of the tissue specific phosph...

journal_title：Atherosclerosis

authors： Hirose T,Kurebayashi S,Kasayama S

更新日期：2001-09-01 00:00:00

abstract：:Free radical mediated oxidation of apoB lipoproteins in the arterial intima appears to contribute to atherogenicity of the entrapped particles. A plausible pathogenic mechanism for oxidation is the one induced by heme leaking from erythrocytes that is then carried into the arterial wall by its high affinity for lipopr...

journal_title：Atherosclerosis

authors： Fernandez AZ,López F,Tablante A,Romano E,Hurt-Camejo E,Camejo G,Apitz-Castro R

更新日期：2001-09-01 00:00:00

abstract：:The response to therapy with hypolipidemic agents shows considerable individual variation. These differences may be due to the interaction of environmental and genetic factors that affect drug bioavailability, receptor function or ligand structure. Our objective was to assess the effect of apolipoprotein (apo) E genot...

journal_title：Atherosclerosis

authors： Pedro-Botet J,Schaefer EJ,Bakker-Arkema RG,Black DM,Stein EM,Corella D,Ordovas JM

更新日期：2001-09-01 00:00:00

abstract：:Thrombomodulin, an endothelial membrane glycoprotein, is an essential part of the protein C anti-coagulant pathway. It may also have a role in the regulation of fibrinolysis. We carried out a cross-sectional study to assess the association of soluble thrombomodulin (sTM) with peripheral artery disease (PAD) in a strat...

journal_title：Atherosclerosis

authors： Salomaa V,Matei C,Aleksic N,Sansores-Garcia L,Folsom AR,Juneja H,Park E,Wu KK

更新日期：2001-08-01 00:00:00

abstract：:Several studies have reported that elevated plasma levels of total homocysteine (tHcy) are related to an increased risk of cardiovascular disease. Only a few studies have looked at the effect of cysteine, another amino thiol, on cardiovascular disease risk. Therefore, in the present case-control study we compared plas...

journal_title：Atherosclerosis

authors： van den Brandhof WE,Haks K,Schouten EG,Verhoef P

更新日期：2001-08-01 00:00:00

abstract：AIM:To determine the prevalence of non-fatal coronary artery disease (CAD) in kindred with Familial Combined Hyperlipidemia (FCHL) in relation to various cardiovascular risk factors and DNA variation in the apo AI-CIII-AIV gene cluster. METHODS AND RESULTS:Data were collected from 18 Dutch FCHL probands, 202 living fi...

journal_title：Atherosclerosis

authors： Voors-Pette C,de Bruin TW

更新日期：2001-08-01 00:00:00